Imprintingenomic<\/span> \u062f\u0631 \u0627\u0631\u06af\u0627\u0646\u06cc\u0633\u0645 \u0647\u0627\u06cc \u0627\u0632 \u0642\u0628\u06cc\u0644 \u067e\u0633\u062a\u0627\u0646\u062f\u0627\u0631\u0627\u0646\u066c \u06af\u06cc\u0627\u0647\u0627\u0646 \u0648 \u062d\u0634\u0631\u0627\u062a \u0646\u06cc\u0632 \u0627\u062a\u0641\u0627\u0642 \u0645\u06cc \u0627\u0641\u062a\u062f. \u0627\u06af\u0631\u0686\u0647 \u0645\u06a9\u0627\u0646\u06cc\u0633\u0645 \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc \u0622\u0646 \u0647\u0646\u0648\u0632 \u0646\u0627\u0634\u0646\u0627\u062e\u062a\u0647 \u0627\u0633\u062a \u0648\u0644\u06cc \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u062f\u0631 \u067e\u0633\u062a\u0627\u0646\u062f\u0627\u0631\u0627\u0646 \u0646\u0634\u0627\u0646 \u062f\u0627\u062f\u0647 \u0627\u0633\u062a \u06a9\u0647 \u0686\u0646\u06cc\u0646 \u0645\u06a9\u0627\u0646\u06cc\u0633\u0645\u06cc \u0628\u0627\u06cc\u062f \u06f4 \u0648\u06cc\u0698\u06af\u06cc \u062f\u0627\u0634\u062a\u0647 \u0628\u0627\u0634\u062f:<\/span><\/span><\/p>\n

\n
1. \u0645\u06a9\u0627\u0646\u06cc\u0633\u0645\u06cc \u0628\u0631\u06af\u0634\u062a \u067e\u0630\u06cc\u0631 \u0628\u0627\u0634\u062f.<\/span><\/span><\/li>\n
2. \u0628\u062a\u0648\u0627\u0646\u062f \u0631\u0648\u0646\u0648\u06cc\u0633\u06cc \u0631\u0627 \u0633\u0627\u067e\u0631\u0633 \u06a9\u0646\u062f.<\/span><\/span><\/li>\n
3. \u062f\u0631 \u0637\u06cc\u0641 \u0641\u0631\u0627\u06cc\u0646\u062f \u06af\u0627\u0645\u062a\u0648\u0698\u0646\u0632 \u0628\u0627\u06cc\u062f <\/span>impose<\/span> \u0634\u0648\u062f.<\/span><\/span><\/li>\n
4. \u0646\u0634\u0627\u0646\u0647 \u062e\u0627\u0635 \u0648\u0627\u0644\u062f\u06cc \u062f\u0631 \u062a\u0645\u0627\u0645 \u0633\u0644\u0648\u0644 \u062f\u06cc\u067e\u0644\u0648\u0626\u06cc\u062f\u06cc <\/span>imprinting<\/span> \u0628\u0627\u06cc\u062f \u062f\u0648\u0628\u0627\u0631\u0647 \u0628\u06cc\u0627\u0646 \u0634\u0648\u062f. <\/span><\/span><\/li>\n<\/ol>\n
   \u062f\u0631\u067e\u062f\u06cc\u062f\u0647 \u0698\u0646\u0648\u0645\u06cc\u06a9 <\/span>imprinting<\/span> \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646\u00a0<\/span>DNA<\/span> \u0628\u06cc\u0634\u062a\u0631 \u0648 \u062f\u0642\u06cc\u0642 \u062a\u0631 \u0645\u0637\u0627\u0644\u0639\u0647 \u0634\u062f\u0647 \u0627\u0633\u062a \u0632\u06cc\u0631\u0627 \u0627\u06cc\u0646 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u0648\u06cc\u0698\u06af\u06cc \u0647\u0627\u06cc \u0622\u062a\u06cc \u067e\u062f\u06cc\u062f\u0647 \u0698\u0646\u0648\u0645\u06cc\u06a9<\/span>\u00a0<\/span>imprinting<\/span> \u0631\u0627 \u062a\u0648\u0636\u06cc\u062d \u0645\u06cc \u062f\u0647\u0646\u062f. \u0628\u0647\u062a\u0631\u06cc\u0646 \u0645\u062b\u0627\u0644 \u0622\u0646 \u0641\u0634\u0631\u062f\u0647 \u0634\u062f\u0646 \u0698\u0646 \u062f\u0631 \u06af\u0627\u0645\u062a \u0645\u0648\u0646\u062b \u0627\u0633\u062a \u06a9\u0647 \u0627\u06cc\u062c\u0627\u062f \u06a9\u0631\u0648\u0645\u0648\u0632\u0648\u0645 \u00d7 \u063a\u06cc\u0631\u0641\u0639\u0627\u0644 \u0631\u0627 \u0645\u06cc \u06a9\u0646\u062f. <\/span><\/span><\/div>\n

   <\/div>\n

   \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 <\/span>DNA<\/span> \u06cc\u06a9 \u062a\u063a\u06cc\u06cc\u0631 \u0627\u067e\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u0627\u0633\u062a \u06a9\u0647 \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u06cc\u06a9 \u0645\u0627\u0631\u06a9\u0631 \u0642\u0627\u0628\u0644 \u062a\u0634\u062e\u06cc\u0635 \u062f\u0631 \u06cc\u06a9 \u0622\u0644\u0644 \u067e\u062f\u0631\u06cc \u062f\u0631 \u0628\u06cc\u0627\u0646 \u0698\u0646 \u0647\u0627\u06cc \u062e\u0627\u0635 \u0645\u06cc \u0628\u0627\u0634\u062f. \u0628\u06cc\u0627\u0646 <\/span>imprint<\/span>\u00a0\u062f\u0631<\/span>\u00a0<\/span>germ line<\/span> \u0627\u0628\u062a\u062f\u0627 \u062f\u0631 \u0645\u0648\u0634 \u0646\u0634\u0627\u0646 \u062f\u0627\u062f\u0647 \u0634\u062f. \u0627\u06a9\u062a\u0633\u0627\u0628 <\/span>imprint<\/span> \u062f\u0631 \u0637\u06cc\u0641 \u0631\u0634\u062f <\/span>post natal<\/span>\u00a0\u062f\u0631 \u0645\u0648\u0634 \u0627\u062a\u0641\u0627\u0642 \u0645\u06cc \u0627\u0641\u062a\u062f. \u0628\u0646\u0627\u0628\u0631\u0627\u06cc\u0646 \u062d\u06a9 \u06a9\u0631\u062f\u0646\u066c \u0628\u06cc\u0627\u0646\u066c \u0646\u06af\u0647\u062f\u0627\u0631\u06cc \u06cc\u06a9 \u067e\u0631\u0648\u0633\u0647 \u062f\u06cc\u0646\u0627\u0645\u06cc\u06a9 \u0645\u06cc \u0628\u0627\u0634\u062f \u06a9\u0647 \u0628\u0627\u06cc\u062f \u0628\u0647 \u0637\u0648\u0631 \u0635\u062d\u06cc\u062d \u0628\u0631\u0646\u0627\u0645\u0647 \u0631\u06cc\u0632\u06cc \u0634\u0648\u062f. \u0627\u06cc\u0646 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u062f\u0631 \u0628\u0627\u0642\u06cc\u0645\u0627\u0646\u062f\u0647 \u0627\u0633\u06cc\u062f\u0647\u0627\u06cc \u0622\u0645\u06cc\u0646\u0647 \u062f\u0631 \u0645\u062d\u0644 \u0647\u0627\u06cc <\/span>CPG<\/span> \u0627\u062a\u0641\u0627\u0642 \u0645\u06cc \u0627\u0641\u062a\u062f \u0648 \u0647\u0627\u06cc\u067e\u0631 \u0645\u062a\u06cc\u0644\u0647 \u0634\u062f\u0646 \u0627\u06cc\u0646 \u062c\u0632\u0627\u06cc\u0631 \u0639\u0645\u062f\u062a\u0627 \u0628\u0627 \u0641\u0634\u0631\u062f\u0647 \u0634\u062f\u0646 \u0698\u0646 \u0647\u0645\u0631\u0627\u0647 \u0627\u0633\u062a. <\/span><\/span><\/div>\n

   <\/div>\n

   \u062a\u062c\u0631\u0628\u06cc\u0627\u062a \u0627\u062e\u06cc\u0631 \u062f\u0631 \u0645\u0648\u0634 \u062a\u0631\u0627\u0646\u0633 \u0698\u0646\u06cc\u06a9 \u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u06cc\u0646 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u0648 \u0698\u0646\u0648\u0645\u06cc\u06a9<\/span>\u00a0<\/span>imprinting<\/span> \u0631\u0627 \u0645\u0634\u062e\u0635 \u06a9\u0631\u062f\u0647 \u0627\u0633\u062a. \u0628\u062e\u0634 \u0645\u0647\u0645\u06cc \u0627\u0632 \u062a\u0631\u0627\u0646\u0633 \u0698\u0646 \u0647\u0627 \u0628\u0631\u0627\u06cc \u0628\u06cc\u0627\u0646 \u0628\u06cc\u0634 \u0627\u0632 \u062d\u062f \u0698\u0646 \u06a9\u0647 \u0647\u0627\u06cc\u067e\u0631\u0645\u062a\u06cc\u0644\u0647 \u0645\u06cc \u0634\u0648\u062f \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0645\u06cc \u06af\u0631\u062f\u062f. \u0627\u0632 \u0627\u0648\u0627\u062e\u0631 \u0633\u0627\u0644 \u06f1\u06f9\u06f8\u06f0 \u062a\u0627 \u06f1\u06f9\u06f9\u06f0 \u0634\u0648\u0627\u0647\u062f \u062c\u062f\u06cc\u062f \u062f\u0631 \u0698\u0646\u0648\u0645\u06cc\u06a9 <\/span>imprinting<\/span> \u0639\u0645\u062f\u062a\u0627 \u0627\u0632 \u0645\u0648\u0634 \u0647\u0627\u06cc \u062a\u0631\u0627\u0646\u0633 \u0698\u0646 \u0648 <\/span>knockout<\/span> \u0628\u062f\u0633\u062a \u0622\u0645\u062f\u0647 \u0627\u0633\u062a.<\/span><\/span><\/div>\n

   <\/div>\n

   \u0628\u0631\u0627\u06cc \u0627\u0648\u0644\u06cc\u0646 \u0628\u0627\u0631 \u0627\u0644\u06af\u0648\u06cc \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u062a\u0631\u0627\u0646\u0633 \u0698\u0646 \u062f\u0631\u0645\u0648\u0634 \u0647\u0627\u06cc \u0646\u0648\u0639 <\/span>outbred cD1<\/span>\u00a0\u0627\u0646\u062c\u0627\u0645 \u0634\u062f. \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u0627\u0646\u062c\u0627\u0645 \u0634\u062f\u0647 \u062f\u0631\u0645\u0648\u0634 \u0647\u0627\u06cc \u062a\u0631\u0627\u0646\u0633 \u0698\u0646\u06cc\u06a9 \u0646\u0634\u0627\u0646 \u0645\u06cc \u062f\u0647\u062f \u06a9\u0647 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 <\/span>DNA<\/span> \u06cc\u06a9 \u0646\u0648\u0639 \u062a\u063a\u06cc\u06cc\u0631 \u0627\u067e\u06cc \u062a\u062d\u062a \u0639\u0646\u0648\u0627\u0646 genomic imprinting <\/span><\/span><\/span>\u00a0\u0698\u0646\u062a\u06cc\u06a9\u06cc \u0627\u0633\u062a<\/span>. <\/span><\/span><\/div>\n

   <\/div>\n

   \u062f\u0631 \u0627\u06a9\u062b\u0631\u06cc\u062a \u0646\u0698\u0627\u062f\u0647\u0627 \u062a\u0631\u0627\u0646\u0633 \u0698\u0646 \u0647\u0627\u06cc \u0648\u0631\u0627\u062b\u062a\u06cc \u0645\u0627\u062f\u0631\u06cc \u0645\u062a\u06cc\u0644\u0647 \u0645\u06cc \u0634\u0648\u0646\u062f \u062f\u0631\u062d\u0627\u0644\u06cc \u06a9\u0647 \u0646\u0648\u0639 \u067e\u062f\u0631\u06cc \u0645\u062a\u06cc\u0644\u0647 \u0646\u0645\u06cc \u0634\u0648\u0646\u062f. \u06cc\u06a9 \u062d\u0627\u0644\u062a \u0627\u0633\u062a\u062b\u0646\u0627 \u0648\u062c\u0648\u062f \u062f\u0627\u0631\u062f \u06a9\u0647 \u06cc\u06a9 \u0647\u0645\u0627\u0647\u0646\u06af\u06cc \u0645\u0633\u062a\u0642\u06cc\u0645 \u0628\u06cc\u0646 \u0648\u0631\u0627\u062b\u062a \u067e\u062f\u0631\u06cc \u0631\u0627 \u0646\u0634\u0627\u0646 \u0645\u06cc \u062f\u0647\u062f \u06a9\u0647 \u0698\u0646 \u0647\u0645 \u0645\u062a\u06cc\u0644\u0647 \u0645\u06cc \u0634\u0648\u062f \u0648 \u0647\u0645 \u0628\u06cc\u0627\u0646 \u0645\u06cc \u06af\u0631\u062f\u062f \u0648 \u0628\u0631 \u0639\u06a9\u0633 \u0622\u0646 \u0648\u0631\u0627\u062b\u062a \u0645\u0627\u062f\u0631\u06cc \u0627\u0633\u062a \u06a9\u0647 \u0645\u062a\u06cc\u0644\u0647 \u0645\u06cc \u0634\u0648\u062f \u0627\u0645\u0627 \u0628\u06cc\u0627\u0646 \u0646\u0645\u06cc \u0634\u0648\u062f. <\/span><\/span><\/div>\n

   <\/div>\n

   \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u0646\u0634\u0627\u0646 \u062f\u0627\u062f\u0647 \u06a9\u0647 \u0627\u0644\u06af\u0648\u0647\u0627\u06cc \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u062f\u0631 \u062a\u0631\u0627\u0646\u0633 \u0698\u0646 \u0647\u0627\u06cc \u067e\u062f\u0631\u06cc \u0648 \u0645\u0627\u062f\u0631\u06cc \u062f\u0631 \u0628\u0644\u0648\u063a \u0633\u0644\u0648\u0644 \u0647\u0627\u06cc <\/span>germ cell<\/span>\u00a0\u0648 \u0646\u06cc\u0632 \u062f\u0631 \u0632\u0645\u0627\u0646 \u0644\u0642\u0627\u062d \u0648 \u062a\u06a9\u0627\u0645\u0644 \u0627\u0648\u0644\u06cc\u0647 \u062c\u0646\u06cc\u0646 \u0648\u062c\u0648\u062f \u062f\u0627\u0631\u062f. \u062f\u0631\u06af\u0627\u0645\u062a \u0647\u0627\u06cc \u0645\u0648\u0646\u062b \u062f\u0631 \u062d\u0627\u0644\u062a \u06a9\u0627\u0645\u0644 \u0698\u0646 \u0647\u0627 \u063a\u06cc\u0631 \u0645\u062a\u06cc\u0644\u0647 \u0647\u0633\u062a\u0646\u062f \u062a\u0627 \u0627\u06cc\u0646\u06a9\u0647 \u0627\u0644\u06af\u0648\u06cc \u0645\u0627\u062f\u0631\u06cc \u0641\u0648\u0631\u0627 \u062a\u062d\u062a \u0628\u0644\u0648\u063a \u0645\u06cc\u0648\u0632\u06cc \u0642\u0631\u0627\u0631\u06af\u06cc\u0631\u062f. \u0627\u0644\u0628\u062a\u0647 \u0627\u06cc\u0646 \u0627\u0644\u06af\u0648\u06cc \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u062f\u0631 \u0627\u0648\u0648\u0633\u06cc\u062a \u0644\u0642\u0627\u062d \u0646\u06cc\u0627\u0641\u062a\u0647 \u0648 \u0628\u062f\u0646\u0628\u0627\u0644 \u0641\u0631\u0627\u06cc\u0646\u062f \u0644\u0642\u0627\u062d \u0628\u062f\u0648\u0646 \u062a\u063a\u06cc\u06cc\u0631 \u0645\u06cc \u0645\u0627\u0646\u062f. \u06af\u0627\u0645\u062a \u0647\u0627\u06cc \u0645\u0627\u062f\u0631\u06cc \u062f\u0631 \u0631\u0648\u0632\u00a0 \u06f1\u06f3 \u062d\u0627\u0645\u0644\u06af\u06cc \u06a9\u0627\u0645\u0644\u0627 \u063a\u06cc\u0631\u0645\u062a\u06cc\u0644\u0647 \u0647\u0633\u062a\u0646\u062f \u0648 \u0627\u06cc\u0646 \u0627\u0644\u06af\u0648 \u062a\u0627 \u0631\u0648\u0632 \u06f1\u06f7 \u062f\u0631 \u062c\u0646\u06cc\u0646 \u062d\u0641\u0638 \u0645\u06cc \u06af\u0631\u062f\u062f. \u0622\u0644\u0644 \u0645\u0627\u062f\u0631\u06cc \u0627\u0644\u06af\u0648\u06cc \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u0631\u0627 \u062f\u0631 \u0637\u06cc \u06f3 \u0631\u0648\u0632 \u0628\u0639\u062f \u0627\u0632 \u0627\u0645\u0628\u0631\u06cc\u0648\u0698\u0646\u0632 \u062d\u0641\u0638 \u0645\u06cc \u06a9\u0646\u062f \u0627\u0645\u0627 \u0622\u0644\u0644 \u067e\u062f\u0631\u06cc \u0647\u0646\u0648\u0632 \u0627\u0644\u06af\u0648\u06cc \u0628\u0644\u0648\u063a \u0631\u0627\u06a9\u0633\u0628 \u0646\u06a9\u0631\u062f\u0647 \u0627\u0633\u062a. \u062d\u062a\u06cc<\/span> \u062f\u0631 \u062c\u0646\u06cc\u0646 \u062f\u0631 \u0645\u0631\u0627\u062d\u0644 \u0627\u0648\u0644\u06cc\u0647 \u0622\u0644\u0644 \u0647\u0627\u06cc \u067e\u062f\u0631\u06cc \u0648 \u0645\u0627\u062f\u0631\u06cc \u067e\u0631\u0648\u0633\u0647 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u062d\u062a\u06cc \u062f\u0631 \u0632\u0645\u0627\u0646 \u0642\u0628\u0644 \u0627\u0632 \u0627\u06a9\u062a\u0633\u0627\u0628 \u0627\u0644\u06af\u0648\u06cc \u0628\u0644\u0648\u063a \u062e\u06cc\u0644\u06cc \u0645\u062a\u0641\u0627\u0648\u062a \u062f\u0627\u0631\u0646\u062f . <\/span><\/span><\/div>\n

   <\/div>\n

   \u0628\u0631\u0646\u0627\u0645\u0647 \u0631\u06cc\u0632\u06cc \u0627\u067e\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u062f\u0631 \u062f\u0648\u0631\u0647 \u0647\u0627\u06cc\u06cc \u0627\u0632 \u06af\u0627\u0645\u062a\u0648\u0698\u0646\u0632\u0648 \u0627\u0645\u0628\u0631\u06cc\u0648\u0698\u0646\u0632 \u0627\u062a\u0641\u0627\u0642 \u0645\u06cc \u0627\u0641\u062a\u062f. <\/span><\/span>\u0627\u06cc\u0646 \u0628\u0631\u0646\u0627\u0645\u0647 \u0631\u06cc\u0632\u06cc \u0645\u0646\u062c\u0631 \u0628\u0647 \u0628\u06cc\u0627\u0646 \u062f\u0648\u0628\u0627\u0631\u0647 \u0627\u0644\u06af\u0648\u0647\u0627\u06cc \u0698\u0646 <\/span>imprinting<\/span> \u0648 \u062e\u0627\u0645\u0648\u0634 \u0634\u062f\u0646 \u06cc\u0627 \u0641\u0639\u0627\u0644 \u0634\u062f\u0646 \u0698\u0646 \u0647\u0627 \u0645\u06cc \u0634\u0648\u062f \u062f\u0631 \u0637\u06cc \u0631\u0634\u062f \u0648 \u0628\u0644\u0648\u063a \u0627\u0648\u0648\u0633\u06cc\u062a \u0622\u0634\u06a9\u0627\u0631 \u0634\u062f\u0647 \u06a9\u0647 \u0622\u0646 \u0647\u0627 \u0646\u0633\u0628\u062a \u0628\u0647 \u0641\u0627\u06a9\u062a\u0648\u0631\u0647\u0627\u06cc \u0645\u062d\u06cc\u0637\u06cc <\/span><\/span>\u0622\u0633\u06cc\u0628 \u067e\u0630\u06cc\u0631 \u0647\u0633\u062a\u0646\u062f \u0648 \u0645\u0645\u06a9\u0646 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0627\u067e\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u0631\u0627 \u062f\u0631 \u0622\u0646\u0647\u0627 \u0627\u0644\u0642\u0627\u0621 \u06a9\u0646\u062f \u0648 \u0628\u0627\u0639\u062b \u0627\u062e\u062a\u0644\u0627\u0644 \u062f\u0631 \u0628\u06cc\u0627\u0646 \u0698\u0646 \u0648 \u0633\u0631\u0627\u0646\u062c\u0627\u0645 \u0646\u0642\u0627\u06cc\u0635 \u06cc\u0627 \u0641\u0642\u062f\u0627\u0646 \u062c\u0646\u06cc\u0646 \u0645\u06cc \u0634\u0648\u062f.\u00a0<\/span><\/span><\/div>\n

   <\/div>\n

   \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u062f\u0631 \u0628\u0631\u062e\u06cc \u0627\u0632 \u0698\u0646 \u0647\u0627\u06cc <\/span>imprint<\/span>\u00a0\u062f\u0631 \u0627\u0648\u0648\u0633\u06cc\u062a \u06cc\u0627 \u062c\u0646\u06cc\u0646 \u0645\u0648\u062c\u0648\u062f \u062f\u0631 \u0645\u062d\u06cc\u0637 \u06a9\u0634\u062a \u0627\u06cc\u0646 \u0627\u062d\u062a\u0645\u0627\u0644 \u0631\u0627 \u0628\u0648\u062c\u0648\u062f \u0622\u0648\u0631\u062f\u0647 \u0627\u0633\u062a \u06a9\u0647 \u0631\u0648\u0634 \u0647\u0627\u06cc <\/span>IVM<\/span> \u0628\u0631 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 <\/span>DNA<\/span> \u062f\u0631 \u0637\u06cc \u0628\u0644\u0648\u063a \u0627\u0648\u0648\u0633\u06cc\u062a \u062a\u0627\u062b\u06cc\u0631 \u0645\u06cc \u06af\u0630\u0627\u0631\u062f. \u0627\u06af\u0631 \u0686\u0647 \u0627\u062b\u0631<\/span>\u00a0<\/span>IVM<\/span> \u0628\u0631 \u067e\u0631\u0648\u0633\u0647 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0647\u06cc\u0633\u062a\u0648\u0646\u06cc \u062f\u0631 \u0627\u0648\u0648\u0633\u06cc\u062a \u06cc\u06a9 \u0645\u06a9\u0627\u0646\u06cc\u0633\u0645 \u0645\u0647\u0645 \u062f\u0631 \u0628\u0631\u0646\u0627\u0645\u0647 \u0631\u06cc\u0632\u06cc \u0627\u067e\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u0627\u0633\u062a \u0627\u0645\u0627 \u0647\u0646\u0648\u0632 \u0627\u06cc\u0646 \u0645\u0648\u0636\u0648\u0639 \u062b\u0627\u0628\u062a \u0646\u0634\u062f\u0647 \u0627\u0633\u062a.<\/span><\/span><\/div>\n

   <\/div>\n

   \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0647\u06cc\u0633\u062a\u0648\u0646 \u0634\u0627\u0645\u0644 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u0644\u06cc\u0632\u06cc\u0646\u0648\u0622\u0631\u0698\u0646\u06cc\u0646\u066c \u0627\u0633\u062a\u06cc\u0644\u0647 \u0634\u062f\u0646 \u0648 \u0641\u0633\u0641\u0631\u06cc\u0644\u0647 \u0634\u062f\u0646 \u0633\u0631\u06cc\u0646\u0648\u062a\u06cc\u0631\u0648\u0646\u06cc\u0646\u066c \u06cc\u0648\u0628\u06cc\u06a9\u0648\u0626\u06cc\u0646\u0647 \u0634\u062f\u0646 \u0644\u06cc\u0632\u06cc\u0646 \u0647\u0645\u0686\u0646\u06cc\u0646 <\/span>ribosylation<\/span> \u0627\u0633\u062a. \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u0646\u0634\u0627\u0646 \u062f\u0627\u062f\u0647 \u0627\u0633\u062a \u06a9\u0647 \u0627\u06cc\u0646 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0647\u06cc\u0633\u062a\u0648\u0646\u06cc \u0646\u0642\u0634 \u0645\u0647\u0645\u06cc \u062f\u0631 \u062a\u0646\u0638\u06cc\u0645 \u0628\u06cc\u0627\u0646 \u0698\u0646 \u062f\u0631 \u0633\u0644\u0648\u0644 \u0647\u0627\u06cc \u0645\u06cc\u062a\u0648\u062a\u06cc\u06a9 \u062f\u0627\u0631\u062f. <\/span>IVM<\/span> \u0627\u062d\u062a\u0645\u0627\u0644 \u062f\u0627\u0631\u062f \u0628\u0627 \u0627\u06a9\u062a\u0633\u0627\u0628 <\/span>Imprinting<\/span> \u0648 \u06cc\u0627 \u062d\u0641\u0638 \u0622\u0646 \u062a\u062f\u0627\u062e\u0644 \u062f\u0627\u0634\u062a\u0647 \u0628\u0627\u0634\u062f. \u062f\u0631 \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u0627\u0646\u062c\u0627\u0645 \u0634\u062f\u0647 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u0698\u0646 <\/span>H19<\/span> \u0631\u0627 \u062f\u0631 \u0645\u0631\u0627\u062d\u0644 \u0645\u062e\u062a\u0644\u0641 \u0628\u0644\u0648\u063a \u0627\u0648\u0648\u0633\u06cc\u062a \u0647\u0627\u06cc \u0628\u0627\u0644\u063a (<\/span>MI<\/span>\u00a0\u066c<\/span>MII<\/span>\u00a0\u066c<\/span>GV<\/span>)\u062f\u0631 <\/span>IVM<\/span> \u0631\u0627 \u062a\u0639\u06cc\u06cc\u0646 \u06a9\u0631\u062f \u0648 \u062a\u0627\u0626\u06cc\u062f\u06cc \u0628\u0631 \u062a\u062d\u0642\u06cc\u0642\u0627\u062a \u0627\u0646\u062c\u0627\u0645 \u0634\u062f\u0647 \u067e\u06cc\u0634 \u062a\u0631 \u0634\u0648\u062f.<\/span><\/span><\/div>\n

   <\/div>\n

   \u062f\u0631\u0637\u06cc \u06f1\u06f0 \u0633\u0627\u0644 \u06af\u0630\u0634\u062a\u0647 IVM<\/span> \u067e\u06cc\u0634\u0631\u0641\u062a \u0647\u0627\u06cc \u0632\u06cc\u0627\u062f\u06cc \u062f\u0627\u0634\u062a\u0647 \u0627\u0633\u062a \u0648 \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u0645\u06cc \u062f\u0647\u062f \u06a9\u0647 \u06f6\u06f2 \u062a\u0627 \u06f8\u06f0\u00a0 \u062f\u0631\u0635\u062f \u0627\u0632 \u0627\u0648\u0648\u0633\u06cc\u062a \u0647\u0627\u06cc \u0628\u0627\u0644\u063a \u062f\u0631 \u06f4\u06f3 \u062a\u0627 \u06f5\u06f4 \u0633\u0627\u0639\u062a \u06a9\u0634\u062a\u0628\u0647 \u0645\u0631\u062d\u0644\u0647\u00a0 \u0645\u06cc\u0648\u0632 \u06f2 \u0645\u06cc \u0631\u0633\u0646\u062f \u06a9\u0647 \u0627\u06cc\u0646 \u0628\u0647 \u062a\u0627\u0631\u06cc\u062e\u0686\u0647 \u0628\u06cc\u0645\u0627\u0631\u06cc \u062f\u0631 \u0641\u0631\u062f \u0648\u0627\u0628\u0633\u062a\u0647 \u0627\u0633\u062a. \u06a9\u0634\u062a \u0637\u0648\u0644\u0627\u0646\u06cc \u0628\u06cc\u0634 \u0627\u0632 \u06f4\u06f8 \u0633\u0627\u0639\u062a \u0628\u0627\u0639\u062b \u0627\u0641\u0632\u0627\u06cc\u0634 \u0631\u06cc\u062a\u0645 \u0628\u0627\u0644\u063a \u0634\u062f\u0646 \u0633\u0644\u0648\u0644 \u0648 \u0628\u0627\u0639\u062b \u062a\u06a9\u0627\u0645\u0644 \u062a\u0627 \u0628\u0644\u0627\u0633\u062a\u0648\u0633\u06cc\u062a \u0645\u06cc \u0634\u0648\u062f. \u062f\u0631 \u0627\u06cc\u0646 \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u06a9\u0634\u062a \u06f2\u06f4 \u0633\u0627\u0639\u062a \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0634\u062f\u0647 \u0627\u0633\u062a. \u06a9\u0647 <\/span>\u0628\u0627\u0639\u062b \u06a9\u0627\u0647\u0634 \u0646\u06cc\u0627\u0632 \u0628\u0647 \u06af\u0646\u0627\u062f\u0648\u062a\u0631\u0648\u067e\u06cc\u0646\u0647\u0627 \u062f\u0627\u0631\u062f \u06a9\u0647 \u06cc\u06a9 \u062c\u0627\u06cc\u06af\u0632\u06cc\u0646 \u0645\u0646\u0627\u0633\u0628 \u0628\u0631\u0627\u06cc \u062c\u0645\u0639 \u0622\u0648\u0631\u06cc \u0627\u0648\u0648\u0633\u06cc\u062a \u0628\u0631\u0627\u06cc \u0633\u06cc\u06a9\u0644 <\/span>IVF<\/span> \u0647\u0633\u062a.<\/span><\/span><\/div>\n

   <\/div>\n

   \u0646\u06a9\u062a\u0647 \u0645\u0647\u0645 \u062f\u06cc\u06af\u0631 \u0627\u06cc\u0646 \u06a9\u0647 \u0645\u0642\u0627\u0644\u0627\u062a \u0627\u062e\u06cc\u0631 \u0646\u0634\u0627\u0646 \u062f\u0627\u062f\u0647 \u062a\u06a9\u0646\u06cc\u06a9 \u06a9\u0645\u06a9 \u0628\u0627\u0631\u0648\u0631\u06cc<\/span>ART<\/span> \u0628\u0627\u0639\u062b \u0627\u06cc\u062c\u0627\u062f \u06cc\u06a9\u0633\u0631\u06cc \u0627\u0634\u062a\u0628\u0627\u0647\u0627\u062a\u00a0<\/span>imprint<\/span> \u0628\u0647 \u0648\u06cc\u0698\u0647 \u062f\u0631 \u0633\u0646\u062f\u0631\u0645 BWS<\/span> \u0645\u06cc \u0634\u0648\u062f \u06a9\u0647 <\/span>\u0627\u06cc\u0646 \u0633\u0646\u062f\u0631\u0645 \u062f\u0631 \u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u0627 <\/span>imprint<\/span> \u063a\u06cc\u0631\u0646\u0631\u0645\u0627\u0644 \u0698\u0646\u00a0<\/span>H19<\/span>\u00a0\u0645\u06cc \u0628\u0627\u0634\u062f.<\/span><\/span><\/div>\n

   \u06cc\u06a9\u06cc \u062f\u06cc\u06af\u0631 \u0627\u0632 \u0627\u06cc\u0646 \u0646\u0642\u0627\u06cc\u0635 \u0634\u0627\u0645\u0644 (<\/span>Large offspring syndrome(Los<\/span>\u00a0\u062f\u0631 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u062a\u06a9\u0646\u06cc\u06a9 <\/span>ART<\/span> \u0627\u06cc\u062c\u0627\u062f \u0645\u06cc \u0634\u0648\u062f \u06a9\u0647 \u0634\u0627\u0645\u0644 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u0646\u0627\u0628\u062c\u0627\u06cc \u0698\u0646 <\/span>IGF2R<\/span> \u0627\u0633\u062a.<\/span><\/span><\/div>\n

   <\/div>\n

   \u0645\u062d\u06cc\u0637 \u06a9\u0634\u062a IVM<\/span><\/h2>\n

   <\/div>\n

   \u0645\u062d\u06cc\u0637 \u06a9\u0634\u062a \u0645\u0648\u0631\u062f \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0628\u0631\u0627\u06cc<\/span>\u00a0<\/span>IVM<\/span> \u06cc\u06a9 \u0646\u0642\u0634 \u0627\u0633\u0627\u0633\u06cc \u0628\u0631\u0627\u06cc \u062a\u06a9\u0627\u0645\u0644 \u0627\u0645\u0628\u0631\u06cc\u0648 \u0648 \u0628\u06cc\u0627\u0646 \u0641\u06cc\u0632\u06cc\u0648\u0644\u0648\u0698\u06cc\u06a9\u06cc \u062f\u0631 \u062c\u0646\u06cc\u0646 \u0631\u0627 \u062f\u0627\u0631\u062f. \u0627\u06cc\u0646 \u0645\u0648\u0636\u0648\u0639 \u0647\u0645 \u062f\u0631 \u0645\u0648\u0634 \u0648 \u0647\u0645 \u062f\u0631 \u0627\u0646\u0633\u0627\u0646 \u0646\u0634\u0627\u0646 \u062f\u0627\u062f\u0647 \u0634\u062f\u0647 \u0627\u0633\u062a. \u062a\u06a9\u0646\u06cc\u06a9<\/span>\u00a0\u0647\u0627\u06cc \u06a9\u0645\u06a9 \u0628\u0627\u0631\u0648\u0631\u06cc\u00a0<\/span>\u0628\u0627 \u06cc\u06a9 \u0627\u0641\u0632\u0627\u06cc\u0634 \u0627\u062e\u062a\u0644\u0627\u0644\u0627\u062a \u0627\u067e\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u062f\u0631\u0628\u0686\u0647 \u0647\u0627\u06cc\u06cc \u06a9\u0647 \u0645\u062a\u0648\u0644\u062f \u0634\u062f\u0647 \u0627\u0646\u062f \u062f\u06cc\u062f\u0647 \u0634\u062f\u0647 \u0627\u0633\u062a.\u00a0<\/span><\/span><\/div>\n

   \u062f\u0631 \u06cc\u06a9 \u0645\u0637\u0627\u0644\u0639\u0647\u060c \u0627\u062e\u06cc\u0631\u0627 \u0646\u0634\u0627\u0646 \u062f\u0627\u062f\u0647 \u0634\u062f\u0647 \u0627\u0633\u062a \u06a9\u0647 \u06cc\u06a9 \u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u06cc\u0646 \u0633\u0648\u067e\u0631 \u0627\u0648\u0648\u0644\u0627\u0633\u06cc\u0648\u0646 \u0648 \u0627\u062e\u062a\u0644\u0627\u0644 \u062f\u0631 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u0698\u0646 <\/span>imprinted<\/span> \u062f\u0631 \u0628\u0644\u0627\u0633\u062a\u0648\u0633\u06cc\u062a \u0648\u062c\u0648\u062f \u062f\u0627\u0631\u062f. <\/span><\/span>\u062f\u0631 \u0627\u06cc\u0646 \u0645\u0637\u0627\u0644\u0639\u0647 \u0645\u0642\u0627\u06cc\u0633\u0647 \u067e\u0631\u0648\u0641\u0627\u06cc\u0644 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u0627\u0632 \u062f\u0648 \u0698\u0646 \u0645\u0627\u062f\u0631\u06cc \u0634\u0627\u0645\u0644 <\/span>Snrpn<\/span> \u0648\u00a0<\/span>peg3<\/span> \u0646\u0634\u0627\u0646 \u062f\u0627\u062f\u0647 \u0634\u062f\u0647 \u0627\u0633\u062a.\u00a0<\/span><\/span>\u062f\u0631 \u0645\u0637\u0627\u0644\u0639\u0647 \u062f\u06cc\u06af\u0631 \u0627\u062b\u0631\u0627\u062a \u0645\u062d\u06cc\u0637 \u06a9\u0634\u062a \u0631\u0627 \u062f\u0631 \u062a\u06a9\u0627\u0645\u0644 \u0627\u0645\u0628\u0631\u06cc\u0648 \u0646\u0634\u0627\u0646 \u062f\u0627\u062f\u0647 \u0634\u062f\u0647 \u0627\u0633\u062a. \u0645\u062d\u0642\u0642\u0627\u0646 \u062d\u0627\u0644\u0627\u062a \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u0631\u0627 \u062f\u0631 \u06f3 \u0698\u0646 <\/span>imprint<\/span> \u0631\u0627 \u0628\u0631 \u0631\u0648\u06cc \u0628\u0644\u0627\u0633\u062a\u0648\u0633\u06cc\u0633\u062a \u062f\u0631 \u06f4 \u0645\u062d\u06cc\u0637 \u06a9\u0634\u062a \u0645\u0642\u0627\u06cc\u0633\u0647 \u06a9\u0631\u062f\u0647 \u0627\u0646\u062f \u0648 \u0645\u0634\u0627\u0647\u062f\u0647 \u06a9\u0631\u062f\u0646\u062f \u06a9\u0647 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0647\u06cc\u0633\u062a\u0648\u0646\u06cc \u06cc\u06a9 \u0646\u0642\u0634 \u0645\u0647\u0645\u06cc \u062f\u0631 \u0637\u06cc \u0627\u0648\u0648\u0698\u0646\u0632 \u062f\u0627\u0631\u0646\u062f. <\/span><\/span><\/div>\n

   <\/div>\n

   \u0627\u0648\u0648\u0633\u06cc\u062a \u0628\u0627\u0644\u063a \u062f\u0631 \u0645\u0648\u0634 \u0628\u0633\u06cc\u0627\u0631\u06cc \u0627\u0632 \u0632\u06cc\u0631 \u0648\u0627\u062d\u062f\u0647\u0627\u06cc <\/span>H1<\/span>\u00a0 \u0648 \u062f\u0631 \u0627\u0648\u0648\u0633\u06cc\u062a \u0645\u06cc\u0648\u0632 \u06f2 \u062f\u0631 \u0645\u0648\u0634 \u0647\u0631 \u06f4 \u0647\u06cc\u0633\u062a\u0648\u0646 \u0627\u0635\u0644\u06cc \u0631\u0627 \u0628\u06cc\u0627\u0646 \u0645\u06cc \u06a9\u0646\u062f. \u0627\u06cc\u0646 \u0641\u0631\u0636\u06cc\u0647 \u0648\u062c\u0648\u062f \u062f\u0627\u0631\u062f \u06a9\u0647 \u0628\u06cc\u0634\u062a\u0631 \u0647\u06cc\u0633\u062a\u0648\u0646 \u0647\u0627 \u062f\u0631 <\/span>mRNA<\/span>\u00a0\u0645\u0627\u062f\u0631\u06cc \u062f\u0631 \u0627\u0648\u0648\u0633\u06cc\u062a \u0647\u0627 \u062f\u0631 <\/span>mRNA<\/span> \u0645\u0627\u062f\u0631\u06cc \u062f\u0631 \u0627\u0648\u0648\u067e\u0644\u0627\u0633\u0645 \u0630\u062e\u06cc\u0631\u0647 \u0648 \u062f\u0631 \u0637\u06cc \u062a\u06a9\u0627\u0645\u0644 \u0627\u0645\u0628\u0631\u06cc\u0648 \u062a\u0631\u062c\u0645\u0647 \u0645\u06cc \u0634\u0648\u062f. \u0647\u0645\u0686\u0646\u06cc\u0646 \u0645\u0627\u0631\u06a9\u0631\u0647\u0627\u06cc \u0627\u067e\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u0645\u0634\u062e\u0635\u06cc \u0628\u0631\u0627\u06cc \u062a\u0634\u06a9\u06cc\u0644<\/span>germ \u00a0line <\/span>\u00a0\u0646\u0631\u0645\u0627\u0644 \u062f\u0631 \u0637\u06cc \u062a\u06a9\u0627\u0645\u0644 \u0627\u0645\u0628\u0631\u06cc\u0648\u0646\u06cc\u06a9 \u0627\u0648\u0644\u06cc\u0647 \u0636\u0631\u0648\u0631\u06cc \u0647\u0633\u062a\u0646\u062f. \u0627\u062e\u062a\u0644\u0627\u0644 \u0627\u067e\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u062f\u0631 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u062a\u06a9\u0646\u06cc\u06a9 <\/span>ART<\/span> \u06cc\u06a9 \u0645\u062b\u0627\u0644\u06cc \u0627\u0632 \u0627\u06cc\u0646 \u06af\u0648\u0646\u0647 \u0645\u0634\u06a9\u0644\u0627\u062a \u0627\u0633\u062a \u0648 \u0647\u0631 \u062f\u0648\u06cc \u0645\u0634\u06a9\u0644\u0627\u062a \u0698\u0646\u062a\u06cc\u06a9\u06cc \u0648 \u0627\u067e\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u062f\u0631 \u0646\u0627\u0628\u0627\u0631\u0648\u0631\u06cc \u0634\u0631\u06a9\u062a \u062f\u0627\u0631\u0646\u062f.<\/span><\/span><\/div>\n

   \u0627\u0648\u0648\u0633\u06cc\u062a \u062f\u0631 \u0645\u062d\u06cc\u0637<\/span>IVM <\/span>\u00a0\u062f\u0631 \u0627\u06a9\u062a\u0633\u0627\u0628 \u06a9\u0627\u0645\u0644 \u0628\u0627\u0632\u0633\u0627\u0632\u06cc \u062f\u0686\u0627\u0631 \u0634\u06a9\u0633\u062a \u0645\u06cc \u06af\u0631\u062f\u062f. \u0632\u06cc\u0631\u0627 \u0628\u0627\u0639\u062b \u0627\u062e\u062a\u0644\u0627\u0644 \u062f\u0631 \u0627\u0633\u062a\u06cc\u0644\u0647 \u0634\u062f\u0646 \u0645\u06cc \u06af\u0631\u062f\u062f. \u0633\u0637\u062d \u0627\u0633\u062a\u06cc\u0644\u0647 \u0634\u062f\u0646 \u0647\u06cc\u0633\u062a\u0648\u0646 <\/span>H3<\/span> \u06cc\u06a9 \u0645\u0639\u06cc\u0627\u0631 \u0628\u0631\u0627\u06cc \u0627\u0631\u0632\u06cc\u0627\u0628\u06cc \u0627\u0633\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u0639\u0645\u0648\u0645\u06cc \u0647\u06cc\u0633\u062a\u0648\u0646 \u062f\u0631 \u06a9\u0631\u0648\u0645\u0627\u062a\u06cc\u0646 \u0645\u06cc \u0628\u0627\u0634\u062f. \u0698\u0646\u0648\u0645 \u0627\u0648\u0648\u0633\u06cc\u062a \u062f\u0631 \u0637\u06cc \u0645\u06cc\u0648\u0632 \u062f\u0648\u0628\u0627\u0631\u0647 \u0633\u0627\u0632\u0645\u0627\u0646\u062f\u0647\u06cc \u0645\u06cc \u0634\u0648\u062f \u0648 \u0628\u0647 \u062f\u0646\u0628\u0627\u0644 \u0622\u0646 \u062f\u0631 \u0632\u0645\u0627\u0646 \u0644\u0642\u0627\u062d \u0646\u06cc\u0632 \u0628\u0647 \u0647\u0645\u06cc\u0646 \u0635\u0648\u0631\u062a \u0645\u06cc \u0628\u0627\u0634\u062f. \u0628\u0631\u0646\u0627\u0645\u0647 \u0631\u06cc\u0632\u06cc \u0627\u067e\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u062f\u0631 \u062f\u0648\u0631\u0647 \u0627\u06cc \u0627\u0632 \u06af\u0627\u0645\u062a\u0648\u0698\u0646\u0632 \u0648 \u0627\u0645\u0628\u0631\u06cc\u0648\u0698\u0646\u0632 \u0627\u062a\u0641\u0627\u0642 \u0645\u06cc \u0627\u0641\u062a\u062f \u0648 \u0627\u06cc\u0646 \u0628\u0631\u0646\u0627\u0645\u0647 \u0631\u06cc\u0632\u06cc \u0645\u0646\u062c\u0631 \u0628\u0647 \u0628\u06cc\u0627\u0646 \u062f\u0648\u0628\u0627\u0631\u0647 \u0627\u0644\u06af\u0648\u0647\u0627\u06cc \u0698\u0646 <\/span>imprinting<\/span> \u0648 \u062e\u0627\u0645\u0648\u0634 \u0634\u062f\u0646 \u06cc\u0627 \u0641\u0639\u0627\u0644 \u0634\u062f\u0646 \u0698\u0646 \u0647\u0627 \u0645\u06cc \u0634\u0648\u0646\u062f. \u062f\u0631 \u0637\u06cc \u0631\u0634\u062f \u0648 \u0628\u0644\u0648\u063a \u0627\u0648\u0648\u0633\u06cc\u062a \u0622\u0634\u06a9\u0627\u0631 \u0634\u062f\u0647 \u0627\u0633\u062a \u06a9\u0647 \u0646\u0633\u0628\u062a \u0628\u0647 \u0641\u0627\u06a9\u062a\u0648\u0631\u0647\u0627\u06cc \u0645\u062d\u06cc\u0637\u06cc \u0622\u0633\u06cc\u0628 \u067e\u0630\u06cc\u0631 \u0647\u0633\u062a\u0646\u062f \u06a9\u0647 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0627\u067e\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u0631\u0627 \u062f\u0631 \u0622\u0646 \u0647\u0627 \u0627\u0644\u0642\u0627\u0621 \u0645\u06cc \u06a9\u0646\u062f \u0648 \u0628\u0627\u0639\u062b \u0627\u062e\u062a\u0644\u0627\u0644 \u062f\u0631 \u0628\u06cc\u0627\u0646 \u0698\u0646 \u0648 \u0633\u0631\u0627\u0646\u062c\u0627\u0645 \u0646\u0642\u0627\u06cc\u0635 \u06cc\u0627 \u0641\u0642\u062f\u0627\u0646 \u062c\u0646\u06cc\u0646 \u0645\u06cc \u0634\u0648\u062f. \u00a0\u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u062f\u0631 \u0628\u0631\u062e\u06cc \u0627\u0632 \u0698\u0646 \u0647\u0627\u06cc <\/span>imprint<\/span> \u062f\u0631 \u0627\u0648\u0648\u0633\u06cc\u062a \u06cc\u0627 \u062c\u0646\u06cc\u0646 \u0645\u0648\u062c\u0648\u062f \u062f\u0631 \u0645\u062d\u06cc\u0637 \u06a9\u0634\u062a \u0627\u06cc\u0646 \u0627\u062d\u062a\u0645\u0627\u0644 \u0631\u0627 \u0628\u0648\u062c\u0648\u062f \u0622\u0648\u0631\u062f\u0647 \u0627\u0633\u062a \u06a9\u0647 \u0631\u0648\u0634 \u0647\u0627\u06cc <\/span>IVM<\/span> \u0628\u0631 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 <\/span>DNA<\/span>\u00a0\u062f\u0631 \u0637\u06cc \u0628\u0644\u0648\u063a \u0627\u0648\u0648\u0633\u06cc\u062a \u062a\u0627\u062b\u06cc\u0631 \u0645\u06cc \u06af\u0630\u0627\u0631\u062f.<\/span><\/span><\/div>\n

   \u0627\u062b\u0631 <\/span>IVM<\/span>\u00a0\u0628\u0631 \u067e\u0631\u0648\u0633\u0647 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0647\u06cc\u0633\u062a\u0648\u0646\u06cc \u062f\u0631 \u0627\u0648\u0648\u0633\u06cc\u062a \u06cc\u06a9 \u0645\u06a9\u0627\u0646\u06cc\u0633\u0645 \u0645\u0647\u0645 \u062f\u06cc\u06af\u0631\u06cc \u062f\u0631 \u0628\u0631\u0646\u0627\u0645\u0647 \u0631\u06cc\u0632\u06cc \u0627\u067e\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u0627\u0633\u062a \u0627\u0645\u0627 \u0647\u0646\u0648\u0632 \u062b\u0627\u0628\u062a \u0646\u0634\u062f\u0647 \u0627\u0633\u062a. \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0647\u06cc\u0633\u062a\u0648\u0646 \u0634\u0627\u0645\u0644 \u0627\u0633\u062a\u06cc\u0644\u0647 \u0634\u062f\u0646 \u0648 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u0644\u06cc\u0632\u06cc\u0646 \u0648\u0622\u0631\u0698\u0646\u06cc\u0646\u066c \u0641\u0633\u0641\u0631\u06cc\u0644\u0647 \u0634\u062f\u0646 \u0633\u0631\u06cc\u0646 \u0648\u062a\u06cc\u0631\u0648\u0646\u06cc\u0646\u066c \u06cc\u0648\u0628\u06cc\u06a9\u0648\u0626\u06cc\u0646\u0647 \u0634\u062f\u0646 \u0644\u06cc\u0632\u06cc\u0646 \u0647\u0645\u0686\u0646\u06cc\u0646 <\/span>ribosylation<\/span> \u0627\u0633\u062a. \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u0646\u0634\u0627\u0646 \u062f\u0627\u062f\u0647 \u0627\u0633\u062a \u06a9\u0647 \u0627\u06cc\u0646 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0647\u06cc\u0633\u062a\u0648\u0646\u06cc \u0646\u0642\u0634 \u0645\u0647\u0645\u06cc \u062f\u0631\u062a\u0646\u0638\u06cc\u0645 \u0628\u06cc\u0627\u0646 \u0698\u0646 \u062f\u0631 \u0633\u0644\u0648\u0644\u0647\u0627\u06cc \u0645\u06cc\u062a\u0648\u062a\u06cc\u06a9 \u062f\u0627\u0631\u062f. \u0627\u0646\u062c\u0627\u0645 <\/span>IVM<\/span> \u0631\u06cc\u062a\u0645 \u0644\u0642\u0627\u062d\u060c \u06a9\u0644\u06cc\u0648\u0627\u0698 \u0648 \u0646\u06cc\u0632 \u0638\u0631\u0641\u06cc\u062a \u062a\u06a9\u0627\u0645\u0644\u06cc \u0631\u0627 \u06a9\u0627\u0647\u0634 \u0645\u06cc \u062f\u0647\u062f.<\/span><\/span><\/div>\n

   \u062f\u0631 \u06cc\u06a9 \u0645\u0637\u0627\u0644\u0639\u0647 \u0627\u062b\u0631 \u0627\u0633\u062a\u06cc\u0644\u0647 \u0634\u062f\u0646 \u0647\u06cc\u0633\u062a\u0648\u0646 \u0631\u0627 \u062f\u0631 \u0627\u0648\u0648\u0633\u06cc\u062a\u060c \u062f\u0631 \u0627\u0645\u0628\u0631\u06cc\u0648 \u0628\u0627 \u06a9\u0644\u06cc\u0648\u0627\u0698 \u0627\u0648\u0644\u06cc\u0647 \u0648 \u062f\u0631 \u0632\u0645\u0627\u0646 \u062f\u0648 \u0633\u0644\u0648\u0644\u06cc \u0628\u0631\u0631\u0633\u06cc \u0648 \u062a\u0627\u0626\u06cc\u062f \u0634\u062f\u0647 \u0627\u0633\u062a \u06a9\u0647 <\/span>IVM<\/span> \u0628\u0631 \u06a9\u06cc\u0641\u06cc\u062a \u0627\u0648\u0648\u0633\u06cc\u062a \u062f\u0631\u0637\u06cc \u067e\u0631\u0648\u0633\u0647 \u0628\u0631\u0646\u0627\u0645\u0647 \u0631\u06cc\u0632\u06cc \u0627\u067e\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u0627\u062b\u0631\u06af\u0630\u0627\u0631 \u0645\u06cc \u0628\u0627\u0634\u062f. \u062a\u0648\u0627\u0646\u0627\u06cc\u06cc \u0631\u0634\u062f \u0641\u0648\u0644\u06cc\u06a9\u0648\u0644 \u062f\u0631\u0645\u062d\u06cc\u0637 \u06a9\u0634\u062a \u0628\u0647 \u062f\u0648\u0632 \u0647\u0648\u0631\u0645\u0648\u0646<\/span><\/span> LH<\/span> \u0628\u0633\u062a\u06af\u06cc \u062f\u0627\u0631\u062f.<\/span>\u00a0<\/span><\/p>\n

   \u062f\u0631 \u06cc\u06a9 \u0645\u0637\u0627\u0644\u0639\u0647 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0627\u0648\u0648\u0633\u06cc\u062a <\/span>bovin<\/span> \u0628\u0631\u0627\u06cc \u062a\u0639\u06cc\u06cc\u0646 \u0645\u0648\u062a\u0627\u0633\u06cc\u0648\u0646 \u0627\u067e\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u06f3 \u0698\u0646 <\/span>imprint<\/span> \u0648 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u062f\u0648 \u0633\u06cc\u0633\u062a\u0645 <\/span>IVM<\/span>\u00a0\u0645\u062e\u062a\u0644\u0641 (<\/span>MSof<\/span>\u066c<\/span>TCM199<\/span>) \u0628\u0631\u0631\u0633\u06cc \u0634\u062f\u0647 \u0627\u0633\u062a. \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0627\u0648\u0648\u0633\u06cc\u062a <\/span>MII<\/span> \u0648 \u0628\u0644\u0627\u0633\u062a\u0648\u0633\u06cc\u062a \u062f\u0631 \u0645\u0648\u0634 \u0633\u0628\u0628 \u0645\u06cc \u0634\u0648\u062f \u06a9\u0647 <\/span>imprinting<\/span>\u00a0\u0645\u0627\u062f\u0631\u06cc \u0627\u062a\u0641\u0627\u0642 \u0627\u0641\u062a\u062f. \u062f\u0631 \u0637\u06cc \u0631\u0634\u062f \u0627\u0648\u0648\u0633\u06cc\u062a \u0648 \u0627\u06a9\u062a\u0633\u0627\u0628 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u0628\u0627 \u0627\u0641\u0632\u0627\u06cc\u0634 \u0642\u0637\u0631 \u0627\u0648\u0648\u0633\u06cc\u062a \u0648 \u0633\u0627\u06cc\u0632 \u0646\u0631\u0645\u0627\u0644 \u0647\u0645\u0631\u0627\u0647 \u0627\u0633\u062a. \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u0627\u0648\u0644\u06cc\u0647 \u062f\u0631 \u0645\u0648\u0634 \u0645\u0634\u062e\u0635 \u0645\u06cc \u06a9\u0646\u062f \u06a9\u0647 \u062f\u0631 \u06a9\u0634\u062a \u06f1\u06f2 \u0631\u0648\u0632\u0647 \u0645\u0646\u062c\u0631 \u0628\u0647 \u0627\u0632 \u062f\u0633\u062a \u062f\u0627\u062f\u0646 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646 \u062f\u0631 <\/span>IGF2<\/span>\u00a0\u0648 <\/span>PEG 1<\/span> \u0648 \u06a9\u0633\u0628 \u0645\u062a\u06cc\u0644\u0627\u0633\u06cc\u0648\u0646\u00a0<\/span>H19<\/span> \u0645\u06cc \u06af\u0631\u062f\u062f. \u0645\u062d\u0642\u0642\u0627\u0646 \u0646\u062a\u06cc\u062c\u0647 \u06af\u06cc\u0631\u06cc \u06a9\u0631\u062f\u0646\u062f \u06a9\u0647 \u0627\u062e\u062a\u0644\u0627\u0644 \u062f\u0631 \u067e\u0631\u0648\u0633\u0647 <\/span>imprinting<\/span> \u062f\u0631 \u0637\u06cc \u0631\u0634\u062f \u0627\u0648\u0648\u0633\u06cc\u062a \u0646\u062a\u06cc\u062c\u0647 \u0627\u06cc \u0627\u0632 \u0647\u0645\u06cc\u0646 <\/span>in vitro folliculogenesis<\/span>\u00a0\u0645\u06cc \u0628\u0627\u0634\u062f.<\/span><\/span><\/p>\n

   \u062f\u0631 \u0637\u06cc \u0631\u0634\u062f \u0627\u0648\u0648\u0633\u06cc\u062a \u0638\u0631\u0641\u06cc\u062a \u0627\u0632 \u0633\u0631\u06af\u06cc\u0631\u06cc \u0645\u06cc\u0648\u0632 \u0648 \u062a\u0648\u0627\u0646\u0627\u06cc\u06cc \u062a\u06a9\u0627\u0645\u0644 \u0627\u0645\u0628\u0631\u06cc\u0648 \u0628\u0647 \u062a\u062f\u0631\u06cc\u062c \u0628\u062f\u0633\u062a \u0645\u06cc \u0622\u06cc\u062f \u0648 \u0646\u06cc\u0627\u0632 \u0628\u0647 \u06cc\u06a9 \u0641\u0639\u0644 \u0648 \u0627\u0646\u0641\u0639\u0627\u0644 \u0635\u062d\u06cc\u062d \u0628\u06cc\u0646 \u0627\u0648\u0648\u0633\u06cc\u062a \u0648 \u0633\u0644\u0648\u0644 \u0647\u0627\u06cc \u0641\u0648\u0644\u06cc\u06a9\u0648\u0644 \u062f\u0627\u0631\u062f \u0648 \u0638\u0631\u0641\u06cc\u062a \u062a\u06a9\u0627\u0645\u0644\u06cc \u0632\u0645\u0627\u0646\u06cc \u06a9\u0647 \u0633\u0646 \u0627\u0648\u0648\u0633\u06cc\u062a \u06a9\u0645 \u0648 \u0632\u06cc\u0627\u062f \u0628\u0627\u0634\u062f \u06a9\u0627\u0647\u0634 \u0645\u06cc \u06cc\u0627\u0628\u062f \u0628\u0646\u0627\u0628\u0631\u0627\u06cc\u0646 \u0644\u0642\u0627\u062d \u0627\u0648\u0648\u0633\u06cc\u062a \u0647\u0627\u06cc \u062e\u06cc\u0644\u06cc \u0645\u0686\u0648\u0631 \u0648 \u06cc\u0627 \u0627\u06cc\u0645\u0645\u0686\u0648\u0631 \u0646\u062a\u0627\u06cc\u062c\u06cc \u0627\u0632 \u0646\u0642\u0627\u06cc\u0635 \u062a\u06a9\u0627\u0645\u0644\u06cc \u0645\u06cc \u0628\u0627\u0634\u062f.\u00a0<\/span><\/div>\n

   \u062f\u0631 \u0686\u0646\u062f\u06cc\u0646 \u06af\u0648\u0646\u0647 \u0627\u0632 \u0642\u0628\u06cc\u0644 \u0645\u0648\u0634\u060c \u0627\u0646\u0633\u0627\u0646\u060c \u0645\u06cc\u0645\u0648\u0646 \u0627\u0646\u062a\u0642\u0627\u0644 <\/span>NSN<\/span>\u00a0\u0628\u0647 <\/span>SN<\/span>\u00a0\u062f\u0631 \u0637\u06cc \u0631\u0634\u062f \u0627\u0648\u0633\u06cc\u062a \u0631\u0627 \u062f\u0627\u0631\u06cc\u0645 \u0648 \u0627\u06cc\u0646 \u0627\u0646\u062a\u0642\u0627\u0644 \u0628\u0627 \u062e\u0627\u0645\u0648\u0634 \u0634\u062f\u0646 \u0631\u0648\u0646\u0648\u06cc\u0633\u06cc \u062f\u0631 \u0637\u06cc <\/span>in vivo<\/span> \u0648 \u0646\u06cc\u0632 \u062f\u0631 <\/span>in vitro<\/span> \u0647\u0645\u0631\u0627\u0647 \u0627\u0633\u062a. \u0698\u0646\u0648\u0645 \u0627\u0648\u0648\u0633\u06cc\u062a \u0647\u0627\u06cc \u0645\u062a\u0645\u0627\u06cc\u0632 \u0634\u062f\u0647 \u0628\u0631\u0627\u06cc \u062a\u0648\u0644\u06cc\u062f \u0627\u0645\u0628\u0631\u06cc\u0648\u0647\u0627\u06cc <\/span>totipotent<\/span>\u00a0\u062f\u0631 \u0637\u06cc \u0645\u06cc\u0648\u0632 \u06cc\u0627 \u0644\u0642\u0627\u062d \u062f\u0648\u0628\u0627\u0631\u0647 \u0628\u0631\u0646\u0627\u0645\u0647 \u0631\u06cc\u0632\u06cc \u0645\u06cc \u0634\u0648\u0646\u062f. \u0627\u06af\u0631 \u0686\u0647 \u0627\u0637\u0644\u0627\u0639\u0627\u062a \u06a9\u0645\u06cc \u062f\u0631\u0628\u0627\u0631\u0647 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a \u0627\u067e\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u0645\u0633\u0626\u0648\u0644 \u0628\u0631\u0627\u06cc \u0628\u0627\u0632\u0633\u0627\u0632\u06cc \u0698\u0646\u0648\u0645 \u0648\u062c\u0648\u062f \u062f\u0627\u0631\u062f \u0627\u0645\u0627 \u0627\u062e\u06cc\u0631\u0627 \u06af\u0632\u0627\u0631\u0634 \u0634\u062f\u0647 \u0627\u0633\u062a \u06a9\u0647 \u062f\u06cc \u0627\u0633\u062a\u06cc\u0644\u0647 \u0634\u062f\u0646 \u0647\u06cc\u0633\u062a\u0648\u0646 \u062f\u0631 \u0627\u0648\u0648\u0633\u06cc\u062a\u0647\u0627\u06cc \u0645\u0648\u0634 \u062f\u0631 \u0637\u06cc \u0645\u06cc\u0648\u0632 \u0627\u062a\u0641\u0627\u0642 \u0645\u06cc \u0627\u0641\u062a\u062f \u0646\u0647 \u062f\u0631 \u0645\u06cc\u062a\u0648\u0632. \u0627\u0633\u062a\u06cc\u0644\u0647 \u0634\u062f\u0646 \u0647\u06cc\u0633\u062a\u0648\u0646 \u0647\u0627\u06cc \u0647\u0633\u062a\u0647 \u0646\u0634\u0627\u0646 \u062f\u0627\u062f\u0647 \u0634\u062f\u0647 \u0627\u0633\u062a \u06a9\u0647 \u06cc\u06a9 \u0646\u0642\u0634 \u0645\u0647\u0645 \u062f\u0631 \u062a\u0646\u0638\u06cc\u0645 \u0628\u06cc\u0627\u0646 \u0698\u0646 \u062f\u0627\u0631\u062f \u0627\u0632 \u0637\u0631\u06cc\u0642 \u062a\u0648\u0644\u06cc\u062f \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a <\/span>conformational<\/span>\u00a0\u062f\u0631 \u0633\u0627\u062e\u062a\u0627\u0631 \u06a9\u0631\u0648\u0645\u0627\u062a\u06cc\u0646 \u062c\u0627\u06cc\u06cc \u06a9\u0647\u00a0<\/span>DNA<\/span> \u0642\u0627\u0628\u0644 \u062f\u0633\u062a\u0631\u0633\u06cc \u0628\u0631\u0627\u06cc \u0641\u0627\u06a9\u062a\u0648\u0631\u0647\u0627\u06cc \u0631\u0648\u0646\u0648\u06cc\u0633\u06cc \u062f\u0631 \u0627\u06cc\u0646\u062a\u0631\u0641\u0627\u0632 \u0628\u0627\u0634\u062f.\u00a0<\/span><\/span><\/div>\n

   <\/div>\n

   \u0627\u0633\u062a\u06cc\u0644\u0647 \u0634\u062f\u0646\u060c \u0628\u0647 \u0639\u0646\u0648\u0627\u0646 \u06cc\u06a9 \u0645\u0627\u0631\u06a9\u0631 \u0627\u067e\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u062f\u0631 \u0627\u0646\u062a\u0642\u0627\u0644 \u0627\u0637\u0644\u0627\u0639\u0627\u062a \u0627\u0632 \u06cc\u06a9 \u0646\u0633\u0644 \u0628\u0647 \u0646\u0633\u0644 \u0628\u0639\u062f \u0639\u0645\u0644 \u0645\u06cc \u06a9\u0646\u062f.\u00a0<\/span><\/div>\n

   <\/div>\n

   \u0645\u0637\u0627\u0644\u0639\u0627\u062a \u0646\u0634\u0627\u0646 \u062f\u0627\u062f\u0647 \u0627\u0633\u062a \u06a9\u0647 \u0633\u06cc\u062a\u0648\u067e\u0644\u0627\u0633\u0645 \u0627\u0648\u0648\u0633\u06cc\u062a \u0634\u0627\u0645\u0644 \u0641\u0639\u0627\u0644\u06cc\u062a \u0647\u0627\u06cc \u0628\u0627\u0632\u0633\u0627\u0632\u06cc \u062f\u0631 \u0633\u0644\u0648\u0644 \u0647\u0627\u06cc \u0645\u062a\u0645\u0627\u06cc\u0632 \u0634\u062f\u0647 \u0645\u06cc \u0628\u0627\u0634\u062f \u0648 \u062f\u0644\u0627\u0644\u062a \u0628\u0631 \u0641\u0627\u06a9\u062a\u0648\u0631 \u0647\u0627\u06cc \u0633\u06cc\u062a\u0648\u067e\u0644\u0627\u0633\u0645\u06cc \u0627\u0648\u0648\u0633\u06cc\u062a \u062f\u0631 \u062f\u06cc \u0627\u0633\u062a\u06cc\u0644\u0647 \u0634\u062f\u0646 \u062f\u0631 \u0632\u0645\u0627\u0646 \u0645\u06cc\u0648\u0632 \u0631\u0627 \u062f\u0627\u0631\u062f.\u00a0<\/span><\/div>\n

   <\/div>\n

   \u0641\u0648\u0644\u06cc\u06a9\u0648\u0644 \u0622\u0646\u062a\u0631\u0627\u0644 \u0628\u0627 \u06cc\u06a9 \u0627\u0648\u0648\u0633\u06cc\u062a \u062d\u0627\u0648\u06cc \u0698\u0631\u0645\u06cc\u0646\u0627\u0644 \u0648\u0632\u06cc\u06a9\u0648\u0644 \u06a9\u0647 \u062d\u0627\u0648\u06cc \u06cc\u06a9 \u06a9\u0631\u0648\u0645\u0627\u062a\u06cc\u0646 \u0645\u062a\u0631\u0627\u06a9\u0645 (<\/span>SN<\/span>) \u0648 \u06cc\u06a9 \u06a9\u0631\u0648\u0645\u0627\u062a\u06cc\u0646 \u067e\u0631\u0627\u06a9\u0646\u062f\u0647 (<\/span>NSN<\/span>) \u0645\u06cc \u0628\u0627\u0634\u062f \u0647\u0645\u0631\u0627\u0647 \u0627\u0633\u062a. \u062f\u0631 \u0645\u0648\u0634 \u0637\u06cc \u0631\u0634\u062f \u0627\u0648\u0648\u0633\u06cc\u062a \u0648 \u0632\u0645\u0627\u0646\u06cc \u06a9\u0647 \u0638\u0631\u0641\u06cc\u062a \u062a\u06a9\u0627\u0645\u0644\u06cc \u0622\u0646 \u0632\u06cc\u0627\u062f \u0645\u06cc \u0634\u0648\u062f \u0627\u0646\u062a\u0642\u0627\u0644 \u0627\u0632 <\/span>NSN<\/span>\u00a0\u0628\u0647 <\/span>SN<\/span> \u0635\u0648\u0631\u062a \u0645\u06cc \u06af\u06cc\u0631\u062f. \u062f\u0631 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u06af\u0646\u0627\u062f\u0648\u062a\u0631\u0648\u067e\u06cc\u0646 \u0647\u0627 \u0627\u06cc\u0646 \u0627\u0646\u062a\u0642\u0627\u0644 <\/span><\/span>\u0627\u0632 <\/span>NSN<\/span> \u0628\u0647\u00a0<\/span>SN<\/span> \u0628\u0627 \u062e\u0627\u0645\u0648\u0634 \u0634\u062f\u0646 \u0698\u0646 \u0647\u0627 \u062f\u0631 \u0645\u062d\u06cc\u0637 <\/span>in vivio<\/span> \u0648 <\/span>in vitro<\/span>\u00a0\u0635\u0648\u0631\u062a \u0645\u06cc \u06af\u06cc\u0631\u062f. \u0647\u0645\u0686\u0646\u06cc\u0646 \u0627\u06cc\u0646 \u0627\u0646\u062a\u0642\u0627\u0644 \u0628\u0627 \u0639\u0628\u0648\u0631 \u0627\u0632 \u0645\u0631\u062d\u0644\u0647 \u067e\u0631\u0647 \u0622\u0646\u062a\u0631\u0627\u0644 \u0628\u0647 \u0645\u0631\u062d\u0644\u0647 \u0622\u0646\u062a\u0631\u0627\u0644 \u0647\u0645\u0631\u0627\u0647 \u0627\u0633\u062a.<\/span><\/span><\/div>\n

   \u062f\u0631 \u0628\u0644\u0648\u063a \u0627\u0648\u0648\u0633\u06cc\u062a \u0647\u0627 \u0639\u0646\u0627\u0635\u0631 \u0645\u062a\u0641\u0627\u0648\u062a\u06cc \u062f\u062e\u0627\u0644\u062a \u062f\u0627\u0631\u0646\u062f \u06a9\u0647 \u0634\u0627\u0645\u0644:<\/span><\/span><\/p>\n

   \u0628\u0644\u0648\u063a \u0647\u0633\u062a\u0647<\/strong> \u0634\u0627\u0645\u0644 \u0634\u0631\u0648\u0639 \u0645\u062c\u062f\u062f \u0645\u06cc\u0648\u0632 \u0648 \u067e\u06cc\u0634\u0631\u0641\u062a \u0628\u0647 \u0633\u0645\u062a \u0645\u06cc\u0648\u0632 <\/span>II<\/span>.\u00a0 <\/span><\/span><\/p>\n

   \u0628\u0644\u0648\u063a \u0633\u06cc\u062a\u0648\u067e\u0644\u0627\u0633\u0645\u06cc \u0648 \u0628\u0644\u0648\u063a \u0698\u0646\u0648\u0645\u06cc<\/strong> \u0647\u0631 \u062f\u0648 \u062f\u0631 \u0633\u0631\u0627\u0633\u0631 \u0631\u0634\u062f \u0627\u0648\u0648\u0633\u06cc\u062a \u0648\u062c\u0648\u062f \u062f\u0627\u0631\u062f. \u0628\u0644\u0648\u063a \u0698\u0646\u0648\u0645\u06cc \u0634\u0627\u0645\u0644 \u062a\u063a\u06cc\u06cc\u0631\u0627\u062a\u06cc \u062f\u0631\u062a\u0648\u0627\u0644\u06cc \u0633\u0627\u062e\u062a\u0627\u0631 <\/span>DNA<\/span> \u0645\u06cc \u0628\u0627\u0634\u062f \u06a9\u0647 \u062f\u0631 \u062a\u0646\u0638\u06cc\u0645 \u0628\u06cc\u0627\u0646 \u0698\u0646 \u0646\u06cc\u0632 \u062f\u062e\u0627\u0644\u062a \u062f\u0627\u0631\u062f.<\/span>\u00a0<\/span><\/p>\n

   \u0627\u0648\u0648\u0633\u06cc\u062a \u062f\u0631\u0645\u0631\u062d\u0644\u0647 \u0698\u0631\u0645\u06cc\u0646\u0627\u0644 \u0648\u0632\u06cc\u06a9\u0644 \u0628\u0627\u0639\u062b \u0628\u06cc\u0627\u0646 (<\/span>interferon regulatory factor(Irf9<\/span>) \u0645\u06cc \u0634\u0648\u062f.<\/span><\/span><\/p>\n

   \u0631\u062a\u06cc\u0646\u0648\u0626\u06cc\u06a9 \u0627\u0633\u06cc\u062f \u0628\u0627\u0639\u062b \u0627\u0644\u0642\u0627\u0621 <\/span>Irf1<\/span> \u0645\u06cc \u0634\u0648\u062f. \u0627\u06cc\u0646 \u0645\u0627\u062f\u0647 \u06cc\u06a9 \u0641\u0631\u0645 \u0641\u0639\u0627\u0644 \u0648\u06cc\u062a\u0627\u0645\u06cc\u0646 <\/span>A<\/span> \u0627\u0633\u062a \u06a9\u0647 \u0628\u0627\u0639\u062b \u0631\u0634\u062f \u0633\u0644\u0648\u0644\u06cc \u0648 \u0628\u0644\u0648\u063a \u0627\u0648\u0648\u0633\u06cc\u062a \u0645\u06cc \u0634\u0648\u062f. \u0647\u0645\u0686\u0646\u06cc\u0646 \u0631\u062a\u06cc\u0646\u0648\u0626\u06cc\u06a9 \u0627\u0633\u06cc\u062f \u0628\u0627\u0639\u062b \u0628\u0644\u0648\u063a \u0633\u06cc\u062a\u0648\u067e\u0644\u0627\u0633\u0645 \u062f\u0631 \u0627\u0648\u0648\u0633\u06cc\u062a <\/span>bovin<\/span> \u0627\u0632 \u0637\u0631\u06cc\u0642 \u062a\u0644\u0641\u06cc\u0642 \u0628\u06cc\u0627\u0646 \u0698\u0646 \u062f\u0631 \u0633\u0644\u0648\u0644\u0647\u0627\u06cc \u06a9\u0648\u0645\u0648\u0644\u0648\u0633 \u2013 \u06af\u0631\u0627\u0646\u0648\u0644\u0648\u0632\u0627 \u0645\u06cc \u0634\u0648\u062f. \u0627\u0644\u0628\u062a\u0647 \u0627\u0636\u0627\u0641\u0647 \u06a9\u0631\u062f\u0646 \u0641\u0631\u0645 \u0633\u06cc\u0633 \u0631\u062a\u06cc\u0646\u0648\u0626\u06cc\u06a9 \u0627\u0633\u06cc\u062f \u0628\u0647 \u0645\u062f\u06cc\u0648\u0645 \u0645\u062d\u06cc\u0637 \u06a9\u0634\u062a \u062d\u0627\u0648\u06cc \u06a9\u0645\u067e\u0644\u06a9\u0633 \u0627\u0648\u0648\u0633\u06cc\u062a \u2013\u06a9\u0648\u0645\u0648\u0644\u0648\u0633 \u0628\u0627\u0639\u062b \u0627\u0641\u0632\u0627\u06cc\u0634 \u062a\u06a9\u0627\u0645\u0644 \u0627\u0645\u0628\u0631\u06cc\u0648 \u0645\u06cc \u0634\u0648\u062f.<\/span><\/span><\/p>\n

   \u0644\u067e\u062a\u06cc\u0646 \u06cc\u06a9 \u0645\u0627\u062f\u0647 \u062f\u06cc\u06af\u0631\u06cc \u0627\u0633\u062a \u06a9\u0647 \u0628\u0647 \u0648\u0633\u06cc\u0644\u0647 \u0622\u062f\u06cc\u067e\u0648\u0633\u06cc\u062a \u0647\u0627 \u0633\u0646\u062a\u0632 \u0645\u06cc \u0634\u0648\u062f. \u0627\u0636\u0627\u0641\u0647 \u06a9\u0631\u062f\u0646 \u0627\u06cc\u0646 \u0645\u0627\u062f\u0647 \u0628\u0647 \u0645\u062d\u06cc\u0637 <\/span>IVM<\/span> \u0628\u0627\u0639\u062b \u0627\u0641\u0632\u0627\u06cc\u0634 \u0631\u0633\u06cc\u062f\u0646 \u0627\u0648\u0648\u0633\u06cc\u062a\u00a0<\/span>Pig<\/span>\u00a0\u0628\u0647 \u0645\u0631\u062d\u0644\u0647 <\/span>MII<\/span> \u0645\u06cc \u0634\u0648\u062f \u0648 \u0646\u0642\u0634 \u0644\u067e\u062a\u06cc\u0646 \u0647\u0645 \u062f\u0631 \u0628\u0644\u0648\u063a \u0627\u0648\u0648\u0633\u06cc\u062a \u0648 \u0647\u0645 \u062f\u0631 \u0628\u0644\u0648\u063a \u0647\u0633\u062a\u0647 \u0645\u06cc \u0628\u0627\u0634\u062f.<\/span><\/span><\/div>\n

   \u00a0<\/span>\u00a0<\/span><\/div>\n

   <\/div>\n

   <\/div>\n

   \u00a0 \u00a0\u062f\u06a9\u062a\u0631 \u0646\u0627\u0635\u0631 \u0633\u0644\u0633\u0628\u06cc\u0644\u06cc \u2013 \u0627\u0633\u062a\u0627\u062f \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u0639\u0644\u0648\u0645 \u067e\u0632\u0634\u06a9\u06cc \u062a\u0647\u0631\u0627\u0646<\/span><\/div>\n

   \u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

   \u0646\u0642\u0634 \u0627\u067e\u06cc \u0698\u0646\u062a\u06cc\u06a9 \u062f\u0631 \u0646\u0627\u0628\u0627\u0631\u0648\u0631\u06cc \u0648 \u0627\u062e\u062a\u0644\u0627\u0644\u0627\u062a \u0698\u0646\u062a\u06cc\u06a9\u06cc \u062f\u0631 \u0628\u0627\u0631\u0648\u0631\u06cc \u0622\u0632\u0645\u0627\u06cc\u0634\u06af\u0627\u0647\u06cc\u00a0 \u0627\u06cc\u0646 \u0645\u0637\u0644\u0628 \u0628\u0647 \u0644\u062d\u0627\u0638 \u0639\u0644\u0645\u06cc \u0628\u0647 \u062a\u0627\u06cc\u06cc\u062f \u0622\u0642\u0627\u06cc \u062f\u06a9\u062a\u0631 \u0646\u0627\u0635\u0631 \u0633\u0644\u0633\u0628\u06cc\u0644\u06cc \u0645\u062a\u062e\u0635\u0635 \u062c\u0646\u06cc\u0646 \u0634\u0646\u0627\u0633\u06cc \u0631\u0633\u06cc\u062f\u0647 \u0627\u0633\u062a. IVF \u0648 \u06a9\u0634\u062a \u062c\u0646\u06cc\u0646\u060c \u06cc\u06a9 \u062f\u0631\u0645\u0627\u0646 \u0645\u0648\u062b\u0631 \u0628\u0631\u0627\u06cc \u0646\u0627\u0628\u0627\u0631\u0648\u0631\u06cc \u0627\u0633\u062a. \u0627\u06af\u0631\u0686\u0647 \u0647\u0632\u06cc\u0646\u0647 \u0647\u0627\u06cc \u0628\u0627\u0644\u0627\u06cc \u0645\u0635\u0631\u0641 \u06af\u0646\u0627\u062f\u0648\u062a\u0631\u0648\u067e\u06cc\u0646 \u0647\u0627 \u0631\u06cc\u0633\u06a9 \u0633\u0646\u062f\u0631\u0645 \u062a\u062d\u0631\u06cc\u06a9 \u067e\u0630\u06cc\u0631\u06cc \u0628\u06cc\u0634 \u0627\u0632\u062d\u062f (\u0647\u0627\u06cc\u067e\u0631 \u0627\u0648\u0648\u0644\u0627\u0633\u06cc\u0648\u0646) \u0631\u0627 \u0628\u0627\u0644\u0627 \u0645\u06cc […]<\/p>\n","protected":false},"author":2,"featured_media":405,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[102,68,6,69],"tags":[99,100,86,101,98,87,83],"_links":{"self":[{"href":"https:\/\/rouyeshfertility.org\/wp-json\/wp\/v2\/posts\/399"}],"collection":[{"href":"https:\/\/rouyeshfertility.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rouyeshfertility.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rouyeshfertility.org\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/rouyeshfertility.org\/wp-json\/wp\/v2\/comments?post=399"}],"version-history":[{"count":9,"href":"https:\/\/rouyeshfertility.org\/wp-json\/wp\/v2\/posts\/399\/revisions"}],"predecessor-version":[{"id":414,"href":"https:\/\/rouyeshfertility.org\/wp-json\/wp\/v2\/posts\/399\/revisions\/414"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/rouyeshfertility.org\/wp-json\/wp\/v2\/media\/405"}],"wp:attachment":[{"href":"https:\/\/rouyeshfertility.org\/wp-json\/wp\/v2\/media?parent=399"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rouyeshfertility.org\/wp-json\/wp\/v2\/categories?post=399"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rouyeshfertility.org\/wp-json\/wp\/v2\/tags?post=399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}